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ESP32 was originally for MIDI and webserver
by Arduino 1 IDE, but ESP32-S3 has in-circuit debugging via
USB-Serial-JTAG peripheral.
SimHub Custom Serial plugin only writes to COM ports, logging responses;
ESP32-S3 board second USB ports can attach to other Windows apps..
ESPConnect checks ESP32 board operation, features
Set speed to 115200 (factory default)
- In Device Manager, check driver installation
- for boards with a single USB port,
- Press and release RST button while holding down BOOT.
- Click ESPConnect CONNECT
Cannot install separate ('portable') Arduino 2 for ESP32 vs STM32.
ESP32-Cx familes have single RISC-V cores.
This page: Arduino and ESP32-S2-Saola-1
Arguably more like single L106 core ESP8266,
ESP32-S2 has a Single-core 240 MHz Xtensa LX7,
while regular ESP32 had dual LX6 microprocessors.

  ESP32-S2-WROOM Data sheet
  ESP32-S2-Saola-1 user guide
There are now also ESP32-S2 boards from LILYGO,
SparkFun,
UnexpectedMaker
Specifically, ESPAsyncWebServer with WebSocket e.g. for MIDI
Gamepad, second serial port and (perhaps) flash filesystem
Did not make a useful composite device e.g. with gamepad and CDC serial;
Wi-Fi MIDI, particularly by WebSocket, seems a promising alternative.
GitHub:
Other:
YouTube: ESP32-S2: How relevant for Makers? First tests
YouTube: Raspberry Pi Pico vs ESP32-S2 and STM32 Blackpill
solderless breadboarding
ESP32-S2-Saola-1 width is inconvenient for 400-point breadboards:

.. but a merely temporary obstacle to anyone with bandsaw access:

ESP32-S2 pin allocations
per libraries/esp32s2LED/src/Servo.h:
// Map Arduino pins to available ESP32-S2 PWM pins
#define PC13 2 // typical LED pin: GPIO0
#define WS2812_PIN 18 // GPIO18 for ESP32-S2-Saola-1M (WROOM)
// 8,9 are SDA, SCL; 15-16 are XTAL; 17 is DAC1; 19-20 are USB; 22-25 are nc
// 26 is Flash; 27-32 are nc; 39-42 are JTAG; 43-44 are COM port; 46 is input-only
#define PB9 6
#define PB8 7
#define PB7 10
#define PB6 11
#define PA10 12
#define PA9 13
#define PA8 14
#define PB1 21
#define PB0 33 // <- level converted
#define PA7 34 // <- level converted
#define PA6 35
#define PA3 36
#define PA2 37 // <- level converted
#define PA1 38 // <- level converted
#define PA15 45
USB OTG pinout

- Green to GPIO20
- White to GPIO19
- Black to - bus
- GND to - bus
Level converter for 5V PWM fans and Servos

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